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Age-related macular degeneration (AMD), characterized by progressive degeneration of retinal pigment epithelium (RPE), is the major cause of irreversible blindness and visual impairment in elderly population.

We previously established a RPE degeneration model using an acute high dose sodium iodate to induce oxidative stress.

P221: Take any precaution to avoid mixing with combustibles, heavy-metal compounds, acids and alkalis. P305 P351 P338: IF IN EYES: Rinse cautiously with water for several minutes.

P313: Get medical advice/ attention.22Inorganic peroxides and oxidants as well as bromine and iodine should be rendered harmless by reduction with acidic sodium thiosulfate solution (Cat.

These low doses are sufficient to retard RPE cell migration and reduced expression of cell junction protein ZO-1.

Phagocytotic activity of RPE cells was attenuated by sodium iodate dose-dependently.

Sodium iodate also increased expression of FGF-2, but suppressed expression of IL-8, PDGF, TIMP-2 and VEGF.

Potassium iodate has been issued as a prophylaxis against radioiodine absorption, & to protect against accumulation of radioactive iodine in the thyroid. Potassium iodate is used as a source for dietary iodine and also an ingredient in some baby formula milk.

Sodium iodate is sometimes found as a conditioner in baking ingredients, and is a minute ingredient in table salt.

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